About this trial
The purpose of this pilot interventional study is to collect preliminary data on administering magnesium sulfate as a neuroprotective medication in patients who achieved Return of Spontaneous Circulation (ROSC) following Cardiac Arrest (CA). The primary aims are to assess the feasibility and safety of administering magnesium and measure serum markers of neuronal injury at prespecified time points in the post-cardiac arrest period. Because this is a pilot study with a limited sample size, the primary objective is to evaluate the precision and stability of the collected measures to inform the design and formal analysis in a larger trial.
Eligibility criteria
Qualifiers
Documented post-cardiac arrest patient with Return of Spontaneous Circulation (ROSC) achieved <2 hours prior to recruitment
Disqualifiers
Age < 18 years or > 85 years
Traumatic cardiac arrests
Unsustained ROSC (<20 minutes)
Patient who is responsive/able to follow motor commands within 1 hour of achieving ROSC
Trial design
Treatments tested in this trial
- Magnesium Sulfate
- Saline
Treatment groups
Sponsors and collaborators
NYU Langone Health
Lead sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator