About this trial
Evaluate the efficacy and safety of ocular surface microbiota transplantation as an adjunctive therapy for dry eye, and explore its impact on the structure of the ocular surface microbiota.
Eligibility criteria
Qualifiers
Aged 18 to 70 years, male or female.
At least one subjective symptom (e.g., dryness, foreign body sensation, burning, fatigue, discomfort, redness, or vision fluctuation).
Fluorescein tear film break-up time (FBUT) ≤ 5 seconds.
Willing and able to actively cooperate with the prescribed course of standard dry eye medications and ocular surface microbiota transplantation therapy for the study duration.
Disqualifiers
History of systemic chronic diseases (e.g., uncontrolled diabetes, autoimmune disorders).
Current or past history of eyelid abnormalities, conjunctival disease, or lacrimal duct obstruction.
History of any ocular surgery or regular wear of corneal contact lenses.
Active infection in the eye(s) or any other part of the body.
Trial design
Treatments tested in this trial
- Ocular surface microbiota transplantation
- Placebo Group