Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial
ConditionMalignant Glioma
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorMayo Clinic
About this trial
This phase I trial finds out the possible benefits and/or side effects of radiosurgery before surgery (preoperative) in treating patients with high grade glioma. Radiosurgery uses special equipment to position the patient and precisely give a single large dose of radiation to the tumor. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. Giving pre-operative radiosurgery may improve the odds of brain tumor control and reduce treatment-related side effects.
Eligibility criteria
Qualifiers
Age >= 18 years
Clear clinical and radiographic evidence of primary high grade glioma (HGG) as judged by the Mayo multidisciplinary neuro-oncology team (World Health Organization [WHO] grade III-IV, including glioblastoma) regardless of IDH and MGMT status
Patients who underwent a previous biopsy confirming high grade glioma are eligible for enrollment
Planned neurosurgical resection of tumor
Disqualifiers
Pregnant women
Nursing women who are unwilling to cease during therapy
Men or women of childbearing potential who are unwilling to employ adequate contraception
Prior history of cranial radiotherapy
Trial design
Treatments tested in this trial
- Radiation Therapy
- Radiosurgery
- Stereotactic Biopsy
- Temozolomide
- Tumor Treating Fields Therapy
- Magnetic Resonance Imaging
- Biospecimen Collection
- Biopsy
- Therapeutic Conventional Surgery
Treatment groups
28 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov