Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries

Trial statusNot yet recruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-65
SponsorAssiut University

About this trial

Post-dural puncture headache (PDPH) or spinal (or post-spinal) headache is one of the most common side effects of spinal anesthesia, with an incidence of 6-36%. The incidence of this complication was reported to be 76-85% after accidental dural puncture in epidural anesthesia. It usually starts within several hours after spinal anesthesia, but sometimes it can be delayed for up to 2 weeks, which usually resolves within a few days

Eligibility criteria

Qualifiers

BMI less than 35 kg/m2

Scheduled for infraumbilical surgeries

American Society of Anesthesiologists (ASA) physical status: I and II

Disqualifiers

ASA physical status more than II.

History of allrgic response to local anaesthetics or any of the medications used in the study

Patients with cognitive impairment

pregnancy

Trial design

Treatments tested in this trial

  • normal Saline
  • Neostigmine
  • Ketorolac

Treatment groups

330 Participants
are divided into 3 treatment groups

Sponsors and collaborators