There is still no evidence of the appropriate dose to be used. Serum magnesium sulfate concentration is not measured regularly, thus we may be using sub-therapeutic level or reaching a toxic level.Overweight and obese women have different pharmacokinetics and different drug distribution, therefore, they may need higher doses of magnesium sulfate to reach therapeutic level.
Age 20-40 years
BMI >25kg/m2
Gestational age > 28 weeks
Intrauterine Fetal Death (IUFD)
Hemolysis - Elevated liver enzymes - Low platelets syndrome (HELLP)
Contraindication to Magnesium Sulfate such as myasthenia gravis, severe renal failure, cardiac ischemia, and heart block
Serum creatinine levels greater than 1.1 mg/dL.