The purpose of this study is to assess the effectiveness and safety of Qingre Huatan formula versus placebo on preventing early neurological deterioration in patients with acute ischemic stroke within 48 hours after onset.
Inpatients diagnosed with acute ischemic stroke. Inpatients diagnosed of acute ischemic stroke.
Meet the criteria of TCM phlegm-heat syndrome
Patients at high-risk of END : Magnetic resonance imaging (MRI) reveals new ischemic lesions, with DWI-ASPECTS score ≤ 7, or presence of at least two risk factors of END.
Acute ischemic stroke within 48 hours after onset.
Received or planned thrombolysis or endovascular therapy after onset.
Suspected secondary stroke caused by brain tumor, brain trauma, hemopathy, etc.
Already dependent in activities of daily living before the present acute stroke (defined as modified Rankin Scare score ≥2 )
Diseases that cause motor dysfunction, including osteoarthritis, etc.