RH Genotype Matched RBC Transfusions
ConditionSickle Cells Disease
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age6+
SponsorChildren's Hospital of Philadelphia
About this trial
To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.
Eligibility criteria
Qualifiers
Subjects age >6 months
Diagnosis of SCD, all genotypes
Require a period of chronic red cell transfusion therapy
Subject/parental/guardian permission (informed consent) and if appropriate, child assent
Disqualifiers
Rare RH genotype that would preclude identification of sufficient RBC units
Antigen negative requirements due to alloimmunization that would preclude identification of sufficient RBC units
Alloimmunized to D antigen
Rh alloimmunized patients for whom providing RH genotype matched blood would expose the patient to an antigen that would not be consistent with standard of care and blood bank protocols
Trial design
Treatments tested in this trial
- Red cell units that are genotype matched at the RHD and RHCE loci
Treatment groups
35 Participants
are divided into 1 treatment groupSponsors and collaborators
Children's Hospital of Philadelphia
Lead sponsor
New York Blood Center
Collaborator
National Heart, Lung, and Blood Institute (NHLBI)
Collaborator
Source ClinicalTrials.gov