Safety and Efficacy of Targeting PP2A in Ovarian Clear Cell Carcinoma Using Dostarlimab and LB-100

Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorM.D. Anderson Cancer Center

About this trial

To learn if the combination of dostarlimab and LB-100 can help to control ovarian clear cell carcinoma

Eligibility criteria

Qualifiers

Ability to provide signed informed consent

Age 18-75 years at time of study entry

Willingness and ability to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up

Histology showing recurrent clear cell ovarian, peritoneal, or fallopian tube cancer (mixed histology with predominant clear cell component is acceptable).

Disqualifiers

Participation in another clinical study with an investigational product (IP) during the last 28 days.

Prior treatment with anti-CTLA-4 or anti-PDL-1/PD-1 antibodies.

Patients with mismatch repair deficient (dMMR) by IHC or microsatellite instability-high tumors

Concurrent treatment on another clinical study, unless it is an observational (non-interventional) clinical study or during the follow-up period of an interventional study.

Trial design

Treatments tested in this trial

  • Dostarlimab
  • LB-100

Treatment groups

21 Participants
are divided into 1 treatment group

Sponsors and collaborators

M.D. Anderson Cancer Center

Lead sponsor

GSK Pharma

Collaborator

Lixte

Collaborator