About this trial
The goal of this clinical trial is to validate if temporal interference brain stimulation (TIBS) is safe in healthy volunteers aged 20 to 65. The main questions it aims to answer are:
* Is it safe to apply TIBS intervention to the left hippocampus in healthy participants? * Is it safe to apply TIBS intervention to the left insula in healthy participants? * Is it safe to apply TIBS intervention to the left anterior cingulate cortex in healthy participants? * Is it safe to apply TIBS intervention to the right inferior frontal cortex in healthy participants?
Participants will:
* Be Randomly allocated to either sham-first group or treat first-group, stratified by stimulated brain region, following a crossover-controlled experimental design * Complete baseline cognitive evaluations and mental status assessments, and undergo a baseline MRI scan on the same day * Receive stimulation for 5 consecutive days, followed by a 2-days washout period, then complete the remaining 5 days of stimulation. * Complete post-intervention cognitive evaluations and mental status assessments, and undergo a post-intervention MRI scan on the same day
Eligibility criteria
Qualifiers
Healthy adults from the community
Age between 20 and 65 years old
No diagnosis of severe psychiatric disorders
No family history of psychiatric diseases
Disqualifiers
Age below 20 years old or above 65 years old
Currently prescribed any medication
Diagnosis of psychiatric disorders (e.g., Major Depressive Disorder, Bipolar Disorder, Schizophrenia)
Diagnosis of neurological disorders (e.g., Dementia, Stroke, Parkinson's disease)
Trial design
Treatments tested in this trial
- Temporal Interference Stimulation - Treatment first
- Temporal Interference Stimulation - Sham first
Treatment groups
8
Treatment groupsSee each treatment group below.