Evaluate the safety and preliminary efficacy of human induced pluripotent stem cell-derived extracellular vesicle (iEV) injection in the treatment of lateral epicondylitis of the humerus.
Diagnosed with lateral epicondylitis by clinical symptom examination and MRI or ultrasound, without obvious tendon tear;
Unilateral lateral elbow pain lasting for more than 12 weeks;
Pain is provoked by at least 2 of the following methods, with a pain VAS score exceeding 3: maximum grip strength, palpation of the lateral epicondyle of the elbow and surrounding area, resisted dorsiflexion of the wrist or middle finger, or stretching of the forearm extensor muscles under a pain-free grip state;
Having received physical therapy or non-steroidal anti-inflammatory drug treatment with poor efficacy;
Complaints of ipsilateral muscle pain caused by other reasons in the past 6 months;
Presence of ipsilateral neurogenic, inflammatory, or systemic joint diseases;
A history of previous lateral epicondylitis (LET) surgery in the past 6 months;
Subjects deemed unsuitable for participating in the trial due to other conditions, as judged by the researcher;