Health Trials

Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD)

ConditionsDepressionSequestra
Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age13-18
SponsorFirst Affiliated Hospital of Chongqing Medical University

About this trial

This project aims to investigate the effectiveness of existing common antidepressants and to provide new evidence for depressed children and adolescents who are not responding to their first treatment.

Eligibility criteria

Qualifiers

Age 13 - 18

As assessed by K-SADS-PL, it meets the DSM-V criteria for MDD with non-psychotic symptoms

Score≥40 on the CDRS-R

Participants with suicidal ideation are eligible, as long as clinicians consider outpatient treatment to be safe

Disqualifiers

History of bipolar disorder, schizophrenia, autism, eating disorders, primary obsessive compulsive disorder, pervasive developmental disorder, or psychosis not otherwise specified

History of serious physical illnesses

Substance abuse or dependence

Current depressive episode with clear suicidal plans or suicidal behavior

Trial design

Treatments tested in this trial

  • Fluoxetine
  • Sertraline
  • Vortioxetine
  • Duloxetine
  • Aripiprazole
  • Lithium Carbonate
  • Olanzapine
  • GCBT

Treatment groups

520 Participants
are divided into 8 treatment groups

8

Treatment groups

See each treatment group below.

Sponsors and collaborators

First Affiliated Hospital of Chongqing Medical University

Lead sponsor

The Second Affiliated Hospital of Chongqing Medical University

Collaborator

Second Xiangya Hospital of Central South University

Collaborator

Children's Hospital of Chongqing Medical University

Collaborator

Source ClinicalTrials.gov