Sequential Treatment of CD19 CARNK and 7x19 CAR-T in R/R B Cell Lymphoma

Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-75
SponsorSecond Affiliated Hospital, School of Medicine, Zhejiang University

About this trial

To study the safety and efficacy of cord blood-derived CD19 CAR-NK cells sequential with 7x19 CAR-T in relapse / refractory B cell lymphoma

Eligibility criteria

Qualifiers

Age 18-75 years old, no gender limit;

Refractory or relapsed DLBCL refers to the failure to achieve complete remission after 2-line treatment; disease progression during any treatment, or disease stable time equal to or less than 6 months; or disease progression or recurrence within 12 months after autologous hematopoietic stem cell transplantation ;

Refractory or relapsed MCL must be resistant to or intolerable to BTK inhibitors;

Refractory or relapsed indolent B-cell NHL is the failure or recurrence of third-line treatment;

Disqualifiers

Allergic to any of the components of cell products;

History of other tumors;

Acute GvHD or extensive chronic GvHD with grade II-IV (Glucksberg standard) in the past or are receiving anti-GVHD treatment;

Had received gene therapy within the past 3 months;

Trial design

Treatments tested in this trial

  • CD19-CAR-NK/T

Treatment groups

52 Participants
are divided into 1 treatment group