Serial MR Imaging and MR Spectroscopic Imaging for the Characterization of Lower Grade Glioma

Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorSusan Chang

About this trial

This trial studies how well serial magnetic resonance (MR) imaging and MR spectroscopic imaging work in characterizing lower grade glioma. Diagnostic procedures, such as MR imaging and MR spectroscopic imaging, may detect serial changes in lower grade glioma. This study may help researchers learn more about practical ways of evaluating and standardizing treatment in patients with brain tumors.

Eligibility criteria

Qualifiers

For patients in cohort 1: histologically proven lower grade glioma who are being followed with surveillance scans

For patients in cohort 2: histologically proven glioma who are scheduled for treatment due to suspected residual or recurrent tumor

Patients with a life expectancy > 12 weeks

Patients must have a Karnofsky performance status of >= 60

Disqualifiers

Subjects will be excluded from participating in this study if they are unable to comply with study and/or follow-up procedures

Trial design

Treatments tested in this trial

  • Hyperpolarized Carbon C 13 Pyruvate
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopic Imaging

Treatment groups

300 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Susan Chang

Lead sponsor

University of California, San Francisco

Sponsor institution

GE Healthcare

Collaborator

Sigma-Aldrich

Collaborator

Phillips-Medisize

Collaborator

National Cancer Institute (NCI)

Collaborator