Single Arm Study of Post-transplant Azacitidine and Chidamide for Prevention of Acute Myelogenous Leukemia Relapse

Trial statusRecruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18-60
SponsorZhujiang Hospital

About this trial

The goal of this clinical research study is to learn if azacitidine combined with Chidamide will help to control the disease in patients with high-risk AML after an allogeneic stem cell transplant. The safety of this combination will also be studied.

Eligibility criteria

Qualifiers

1.Age 18 to 60 years old,both male and female

2.Be able to understand and sign informed consent

3.Patients with a diagnosis of AML not M3 according to the 2016 World Health Organization (WHO) Acute Myeloid Leukemia Classification and Diagnostic

4.Patients have AML with poor genetic abnormalities,primary refractory AML,relapsed AML or secondary AML

Disqualifiers

1.Uncontrollable active infection

2.Patients with active hepatitis B or C or HIV infection before enrollment

3.Have a grade III-IV graft-versus-host disease

Trial design

Treatments tested in this trial

  • Azacitidine
  • Chidamide

Treatment groups

20 Participants
are divided into 1 treatment group

Sponsors and collaborators