Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones
Trial statusNot yet recruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of California, Los Angeles
About this trial
Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications.
Prescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and/or decrease the risk of future kidney stones. However, efficacy of alternatives to potassium potassium citrate are not well studied.
This study seeks to evaluate sodium bicarbonate and assess its ability to alkalinize urine in a cohort of patients with kidney stones and compare this to prescription potassium citrate.
Eligibility criteria
Qualifiers
Adult >18 years of age
History of nephrolithiasis
One 24h urine collections within one year of enrollment with hypocitraturia.
Patients currently utilizing or considering use of Kcit for stone prevention
Disqualifiers
Individuals with known metabolic disorders
Individuals with other known causes of nephrolithiasis
Anyone who, in the opinion of the PI, is unfit or unsuitable to participate in the study
Trial design
Treatments tested in this trial
- Potassium Citrate
- Sodium Bicarbonate
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of California, Los Angeles
Lead sponsor
University of California, Davis
Collaborator
Brigham and Women's Hospital
Collaborator
Landspitali University Hospital
Collaborator
University of California, San Diego
Collaborator
Centre hospitalier de l'Université de Montréal (CHUM)
Collaborator
Source ClinicalTrials.gov