Evaluate the safety and tolerability of BPI-572270 in adult patients with specific RAS mutant advanced solid tumors.
Histologically confirmed advanced solid tumor with RAS mutations identified through deoxyribonucleic acid (DNA) sequencing.
Have received prior standard therapy appropriate for tumor type and stage.
Have Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Adequate organ function.
Primary central nervous system (CNS) tumors active and untreated brain metastases.
Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication.
History of any other unstable or clinically significant concurrent medical condition that would, in the opinion of the investigator, jeopardize the safety of a participant, impact their expected survival through the end of the study participation, and/or impact their ability to comply with the protocol prior/concomitant therapy