About this trial
Most studies of bloating have focused on functional factors, while data on organic abdominal distention are rare, and studies that combine small intestine bacterial overgrowth and/or oral cecum transit time abnormalities are more urgent to explore. On this basis, patients with functional abdominal distension complicated with small intestine bacterial overgrowth were divided according to whether there was abnormal oral cecum transit time, and given the same treatment plan. The relief effect of abdominal distension, small intestine bacterial overgrowth turning negative and oral cecum transit time recovery were observed, so as to further clarify the cause of abdominal distension patients.
Eligibility criteria
Qualifiers
Age 18-60 years old and gender;
The chief complaint is abdominal distension and/or abdominal distension, abdominal distension and/or abdominal distension more prominent than other symptoms.
Patients with functional abdominal distension and small intestinal bacterial overgrowth were selected in Part 1;
No drug contraindications.
Disqualifiers
Preparation for pregnancy, pregnancy, breastfeeding women, or overall poor compliance, or other conditions that the investigator believes need to be excluded;
History of malignant tumors, history of abdominal surgeries;
Food intolerance, confirmed or suspected lactose intolerance;
Diagnosis of urinary system (chronic kidney disease, etc.), immune system (scleroderma, etc.), nervous system (Parkinson's disease, etc.), mental system (depression, etc.) and other diseases outside the digestive system;
Trial design
Treatments tested in this trial
- Rifaximin
Treatment groups
Locations
Sponsors and collaborators
Peking Union Medical College Hospital
Lead sponsor
Navy General Hospital, Beijing
Collaborator
Air Force Military Medical University, China
Collaborator
Beijing Tongren Hospital
Collaborator
Beijing Friendship Hospital
Collaborator
Beijing Chao Yang Hospital
Collaborator
Beijing Tiantan Hospital
Collaborator
The Luhe Teaching Hospital of the Capital Medical University
Collaborator
China-Japan Friendship Hospital
Collaborator
Beijing Aerospace General Hospital
Collaborator
Beijing Jishuitan Hospital
Collaborator
Peking University Third Hospital
Collaborator