Health Trials

Study of SGR-1505 in Mature B-Cell Neoplasms

ConditionsMature B-Cell NeoplasmNon Hodgkin LymphomaDLBCLWaldenstrom MacroglobulinemiaMALT LymphomaFollicular LymphomaPediatric-Type Follicular LymphomaIRF4 Gene RearrangementEBV-Positive DLBCL, NosBurkitt LymphomaPlasmablastic LymphomaHigh-grade B-cell LymphomaPrimary Cutaneous Follicle Center LymphomaPrimary Effusion LymphomaMantle Cell LymphomaDLBCL Germinal Center B-Cell TypePrimary Mediastinal Large B Cell LymphomaT-Cell/Histiocyte Rich LymphomaALK-Positive Large B-Cell LymphomaPrimary Cutaneous Diffuse Large B-Cell LymphomaSplenic Marginal Zone LymphomaChronic Lymphocytic LeukemiaNodal Marginal Zone LymphomaHHV8-Positive DLBCL, NosLymphoplasmacytic LymphomaDuodenal-Type Follicular Lymphoma
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorSchrödinger, Inc.

About this trial

The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or recommended dose (RD) of SGR-1505.

Eligibility criteria

Qualifiers

Subject must have a history of histologically or cytologically confirmed mature B-cell malignancy.

Subject must have measurable or detectable disease according to the applicable disease-specific classification system and meet criteria for initiation of treatment.

Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

Life expectancy ≥ 12 weeks.

Disqualifiers

The subject is in need of immediate cytoreductive therapy (unless the patient has no remaining treatment choice with potential benefit).

Subject has previous invasive malignancy in the last 2 years.

Subject has a known allergy to SGR-1505 or excipients of SGR-1505.

Subject has symptomatic or active CNS involvement of disease.

Trial design

Treatments tested in this trial

  • SGR-1505

Treatment groups

98 Participants
are divided into 1 treatment group

Sponsors and collaborators

Schrödinger, Inc.

Lead sponsor

Source ClinicalTrials.gov