The Effect of Chimeric Antigen Receptor (CAR)-T Cell Therapy on the Reconstitution of HIV-specific Immune Function

ConditionHIV/AIDS
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18-60
SponsorGuangzhou 8th People's Hospital

About this trial

To study the safety and effectiveness of CAR-T Cell therapy on HIV patients whose plasma HIV has been successfully suppressed after cART, which is expected to enhance the res-constitution of HIV-specific immune function to assist the eradication of HIV reservoir.

Eligibility criteria

Qualifiers

HIV infection confirmed.

Receiving cART more than 12 months.

HIV viral-load < 50 copies/ml and CD4 cell count more than 350 cells/ul.

Without serious liver, heart, liver and kidney diseases.

Disqualifiers

With active HBV or HCV infection, or serious opportunistic infections.

With serious chronic disease such like diabetes, the mental illness,et al

History of suffering from pancreatitis during cART.

Pregnant or breast-fed.

Trial design

Treatments tested in this trial

  • CAR-T cells

Treatment groups

40 Participants
are divided into 1 treatment group

Sponsors and collaborators

Guangzhou 8th People's Hospital

Lead sponsor

Sun Yat-sen University

Collaborator