This is prospective double-blinded placebo-randomized controlled trial that aims to compare the effect of preoperative administration of oral duloxetine 60 mg on decreasing the incidence of postoperative delirium in cancer patients undergoing surgery.
All patients will sign an informed consent prior to inclusion in the study.
Adult patients with ASA class I-III, undergoing cancer surgery.
Patients with pre-existing neuro- cognitive dysfunction.
Documented signs of dementia after psychiatric evaluations.
Language barriers or deafness.
Psychosis stroke, meningitis, or brain tumors
Amira Hassan Ahmed Ali
Lead sponsor
Assiut University
Sponsor institution