Health Trials

The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)

ConditionsAlcohol Use Disorder (AUD)Alcohol-Related DisordersAlcohol Use
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age21-65
SponsorYale University

About this trial

This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.

Eligibility criteria

Qualifiers

Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) diagnosis of Alcohol Use Disorder

Medically healthy

Ability to provide consent

Disqualifiers

Unstable medical conditions

Trial design

Treatments tested in this trial

  • 0.3mg/kg/min Dimethyltryptamine + Normal Saline infusion
  • 0.2 mg/kg/min + Dimethyltryptamine 0.01mg/kg/min infusion
  • 25 mg Diphenhydramine (5 min) + Normal Saline

Treatment groups

63 Participants
are divided into 3 treatment groups

Sponsors and collaborators

Yale University

Lead sponsor

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Collaborator

Source ClinicalTrials.gov