The Safety, Feasibility, and Repeatability of Inhaled ATP Cough Challenges
Trial statusRecruiting
Trial phasePhase 1
Trial typeInterventional
Biological sexAll
Age18+
SponsorMcMaster University
About this trial
The inhalation of adenosine 5'-triphosphate (ATP) to evoke cough (ATP cough challenge) is becoming increasingly used as a tool to measure cough hypersensitivity in patients with chronic cough. However, the safety, feasibility, and repeatability of this procedure is not widely known. In this study, we will perform ATP cough challenges in healthy individuals and in patients with mild asthma and chronic cough to better understand the safety, feasibility, and repeatability of these challenges. Such information will guide the future conduct of ATP cough challenges to measure cough hypersensitivity and identify patients who may better respond to ATP-blocking therapies.
Eligibility criteria
Qualifiers
Normal spirometry; and
No current or past medical history of chronic cough or other respiratory diseases.
Disqualifiers
Unable to perform acceptable and reproducible spirometry;
Have unresolved symptoms of upper respiratory tract infection within 6 weeks prior to the first study visit;
Have had a lower respiratory tract infection or pneumonia within 6 weeks prior to the first study visit;
Presence of other primary pulmonary disorders, including pulmonary embolism, pulmonary hypertension, lung cancer, cystic fibrosis, radiologically-proven emphysema, severe bronchiectasis, or severe interstitial lung disease; or
Trial design
Treatments tested in this trial
- Adenosine 5'-triphosphate
Treatment groups
33 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov