A Phase I Study to Assess the Safety, Tolerability and Preliminary Efficacy of Derived Motor Neuron Progenitor Cells (XS228CN) in Subjects with Amyotrophic Lateral Sclerosis
18-75 years of age (inclusive of 18 and 75 years), regardless of gender;
Diagnosed of definite or probable ALS according to the revised EI Escorial criteria;
Respiratory function FVC at baseline was ≥70% of the predicted value (FVC%);
Patients with birth-potential (both male and female) must agree to use effective non-drug contraceptive measures from the time of signing the informed consent until 6 months after the conclusion of the trial;
Subject has signs and symptoms of neuromuscular weakness, and other causes of muscle weakness cannot be ruled out;
Baseline body mass index (BMI) < 18.5 kg/m²;
Primary lateral sclerosis presenting only with upper motor neuron symptoms;
Significant psychiatric disorders that the investigator assesses may affect evaluation;