Penetrating keratoplasty is a cornea surgery involving several inflammatory complications, of which the most important is glaucoma. Researchers wish to determine whether it is safe to administer infliximab (an anti-inflammatory drug) eye drops after surgery, and whether this eye drop could prevent the occurrence of glaucoma.
Age between 18 and 80 years;
First corneal transplant surgery;
Capable of providing informed consent;
Capable of administering eye medication or access to a caregiver able and willing to administer the eye medication for the patient.
Active ocular infection;
Past corneal transplant (any technique);
Advanced glaucoma or macular disease;
Active or latent systemic infection (tuberculosis, histoplasmosis, coccidioidomycosis, cytomegalovirus, pneumocystis, aspergillosis or hepatitis B);
Centre hospitalier de l'Université de Montréal (CHUM)
Lead sponsor
Fonds de recherche en ophtalmologie de l'Université de Montréal
Collaborator
Maisonneuve-Rosemont Hospital
Collaborator
Niagara Health System
Collaborator
Prism Eye Institute
Collaborator
Ottawa Hospital Research Institute
Collaborator