Vedicitumomab Alone or in Combination for the Treatment of Locally Advanced or Metastatic SDC

Trial statusNot yet recruiting
Trial phasePhase 1, Phase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorPeking Union Medical College

About this trial

(1) To apply Bayesian statistics to screen for the most effective treatment regimen containing recombinant humanized anti-HER2 monoclonal antibody-MMAE coupling agent vedicitumomab (Edisil, RC48) for locally advanced or metastatic salivary gland ductal carcinoma expressing HER2 in the near future. (2) To explore biomarkers relevant to the efficacy of recombinant humanized anti-HER2 monoclonal antibody-MMAE-coupled vedicitumomab (Edisil, RC48) in the treatment of HER2-expressing locally advanced or metastatic salivary gland ductal carcinoma.

Eligibility criteria

Qualifiers

None

Disqualifiers

None

Trial design

Treatments tested in this trial

  • vedicitumomab (Edisil, RC48)
  • vedicitumomab in combination with pyrrolizidine
  • RC48 in combination with a platinum-based chemotherapeutic agent
  • RC48 in combination with teraplizumab

Treatment groups

120 Participants
are divided into 4 treatment groups

Locations

This trial has no locations

Sponsors and collaborators