A Clinical Study of SHR-1701 Combined With Chemotherapy for the Perioperative Treatment of Locally Advanced Resectable Siewert Type II Adenocarcinoma of the Esophagogastric Junction

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorHebei Medical University Fourth Hospital

About this trial

Evaluating the efficacy and safety of SHR-1701 combined with chemotherapy for the perioperative treatment of locally advanced resectable Siewert type II adenocarcinoma of the esophagogastric junction.

Eligibility criteria

Qualifiers

HB≥90g/L;

ANC≥1.5×109/L;

PLT≥100×109/L;

ALT and AST<2.5ULN(liver metastasis: ALT and AST<5ULN);

Disqualifiers

Known signs of active bleeding from the lesion (except for a positive fecal occult blood test);

Diagnosis of HER2-positive adenocarcinoma of the stomach or gastroesophageal junction;

Cardia or pyloric obstruction;

Currently participating in an interventional clinical trial, or having received treatment with another investigational drug or device within 4 weeks prior to the first dose;

Trial design

Treatments tested in this trial

  • SHR-1701+SOX

Treatment groups

38 Participants
are divided into 1 treatment group