A Dose-finding Study of JMKX003142 in Treatment of Renal Edema
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorJemincare
About this trial
To Evaluate the Safety, Efficacy, and Pharmacokinetic Characteristics of JMKX003142 Administered Randomly, Open-label, Active-controlled Study in Chinese Renal Edema Patients.
Eligibility criteria
Qualifiers
Patients who can fully understand the purpose and process of the study and voluntarily sign the informed consent form（ICF）;
Age ≥ 18 years old during screening;
Diagnosed as renal edema during screening;
Estimated glomerular filtration rate（eGFR） ≥ 15 mL/min/1.73m2 during screening.
Disqualifiers
Patients who are receiving the renal replacement therapy during screening or patients who require renal replacement therapy in the short term evaluated by the researchers;
Patients who are suspected with hypovolemia;
Patients with the following diseases or symptoms: acute thrombosis, diarrhea, and difficulty urinating;
Patients who are unable to sense thirst or who have difficulty with fluid intake;
Trial design
Treatments tested in this trial
- JMKX003142 tablets
- Torasemide tablets
Treatment groups
216 Participants
are divided into 4 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov