A Exploratory Study on Untreated Follicular Lymphoma With Orelabrutinib, Tafasitamab, and Lenalidomide

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorInstitute of Hematology & Blood Diseases Hospital, China

About this trial

Evaluate the efficacy and safety of orelabrutinib, tafasitamab, and lenalidomide in the first-line treatment of patients with follicular lymphoma.

Eligibility criteria

Qualifiers

Age > 18 years, regardless of gender;

Newly diagnosed patients with follicular lymphoma (Grade 1, 2, or 3a) confirmed histologicallyaccording to the World Health Organization (WHO) classification of diseases;

Deemed by the investigator to have an indication for treatment and require therapy;

ECOG performance status score of 0-2;

Disqualifiers

Women with a positive serum pregnancy test or who are breastfeeding;

Patients with lymphoma involving the central nervous system (CNS);

Clinically significant heart disease, including unstable angina, acute myocardial infarction within6 months prior to randomization, congestive heart failure with New York Heart Association(NYHA) functional class IIl or IV, or left ventricular ejection fraction <50%;

Patients with grade >2 neuropathy;

Trial design

Treatments tested in this trial

  • Orelabrutinib
  • Tafasitamab
  • Lenalidomide

Treatment groups

27 Participants
are divided into 1 treatment group