A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Colorectal Cancer
ConditionColorectal Cancer
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorVerastem, Inc.
About this trial
This study will assess the safety and efficacy of VS-7375 alone and in combination with cetuximab or panitumumab and cetuximab plus mFOLFOX in patients with metastatic KRAS G12D - mutated Colorectal Cancer
Eligibility criteria
Qualifiers
Histopathology confirmed metastatic CRC
Measurable disease per RECIST 1.1
Local testing confirmed KRAS G12D mutation (tissue required for confirmatory central testing)
ECOG PS=0 or 1
Disqualifiers
Have any other documented co-existing common RAS mutation(s)
Prior anti-cancer Tx within 4 weeks or drug-specific timeline within first treatment dose, whichever shorter
Major surgery within 4 weeks of first treatment dose
Radiation therapy (RT) within 1 week of first treatment dose
Trial design
Treatments tested in this trial
- VS-7375
- cetuximab
- panitumumab
- Cetuximab + mFOLFOX6
Treatment groups
150 Participants
are divided into 3 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov