A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-80
SponsorVertex Pharmaceuticals Incorporated

About this trial

The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).

Eligibility criteria

Qualifiers

Age 18-80 years

Diagnosis of generalized myasthenia gravis with generalized muscle weakness and fitting MGFA clinical classification II-IV

Additional inclusion criteria are defined in the protocol

Disqualifiers

History of thymic surgery within 6 months of screening

History of malignancy within the last 5 years

Additional exclusion criteria are defined in the protocol

Trial design

Treatments tested in this trial

  • Povetacicept
  • Placebo

Treatment groups

30 Participants
are divided into 2 treatment groups