A Phase II Trial of Perioperative Adebrelimab Combined With XELOX in Resectable Locally Advanced Gastric/Gastroesophageal Junction Cancer (GC/GEJC)

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorTianjin Medical University Cancer Institute and Hospital

About this trial

To observe and evaluate the efficacy and safety of adebrelimab combination chemotherapy regimen in the perioperative treatment of surgically resectable gastric cancer/adenocarcinoma of the gastroesophageal junction.

Eligibility criteria

Qualifiers

Patients voluntarily enrolled in the study and signed an informed consent form

18-75 years old, male and female gender are not limited

Gastric adenocarcinoma or adenocarcinoma of the gastroesophageal junction as determined by pathologic histology

Clinical staging of II-III/T3-4aNxM0 (AJCC 8th edition cTNM staging of gastric cancer)

Disqualifiers

patients who are pregnant or breastfeeding

Received prior anti-tumor therapy, including chemotherapy, radiotherapy, targeted therapy, or immunotherapy

other malignant tumor (except basal or squamous cell carcinoma, superficial bladder cancer, cervical cancer in situ or breast cancer) within the past 5 years

Uncontrolled pleural effusion, pericardial effusion or ascites

Trial design

Treatments tested in this trial

  • Adebrelimab
  • XELOX

Treatment groups

25 Participants
are divided into 1 treatment group