About this trial
The goal of this small (n=75) proof-of-concept randomized clinical trial is to test the effects of transcranial alternating current stimulation (tACS) during motivational interviewing (MI) sessions with participants who drink at above the low-risk level. Participants will be randomized to receive either MI with active stimulation, MI with sham stimulation, or a delayed treatment group that receives MI with no stimulation. Measures will include brain imaging, alcohol use, cannabis use, risk-taking behavior, emotions, and others. Participants who are randomized to the delayed-treatment group will not receive brain imaging.
Eligibility criteria
Qualifiers
Self-identify as having problem drinking
Right-handed
Age 21-60 years
AUDIT score indicating risky drinking
Disqualifiers
Left-handed or ambidextrous
Currently engaged in treatment for alcohol use disorder
Receiving treatment for alcohol use disorder within the prior 12 months
History of brain injury or neurological diagnosis
Trial design
Treatments tested in this trial
- High-density transcranial alternating current stimulation
- Sham stimulation
- Motivational interviewing
Treatment groups
Sponsors and collaborators
The Mind Research Network
Lead sponsor
National Institute of General Medical Sciences (NIGMS)
Collaborator