About this trial
Exploring the efficacy and safety of adaptively adjusting treatment regimens based on ctDNA (MRD) status for EGFR mutation-positive NSCLC
Eligibility criteria
Qualifiers
Sign a written informed consent before implementing any trial-related procedures;
At least 18 years of age;
Have histologically or cytologically confirmed non-squamous non-small cell lung cancer.
Confirmed presence of EGFR-sensitive mutation-positive by tumor histology, cytology, hematology, or pleural effusion supernatant;
Disqualifiers
The pathology is small cell lung cancer (SCLC), including lung cancer with a mixture of SCLC and non-small cell lung cancer (NSCLC);
received systemic anti-tumor therapy within 3 weeks before treatment, such as chemotherapy, targeted therapy, immunotherapy (including Chinese herbal medicine therapy with anti-tumor indications), etc.;
received any investigational drug therapy within 4 weeks before treatment;
received high-dose immunosuppressive drugs (systemic glucocorticoids exceeding 10mg/day of prednisone or its equivalent dose) within 4 weeks before treatment;
Trial design
Treatments tested in this trial
- Firmonertinib
- Firmonertinib/pemetrexed/Carboplatin
- Firmonertinib/pemetrexed/Carboplatin/Bevacizumab