To find out if local consolidation therapy (such as radiation therapy with or without other local therapies such as surgery, ablation \[the removal or destruction of a body part or tissue or its function\], or embolization \[a procedure that uses particles, such as tiny gelatin sponges or beads, to block a blood vessel\]) to all progressive sites of disease can help to control the disease compared with next-line systemic therapy.
Age ≥18
Histologically or cytologically confirmed stage IV cancer.
Eastern Cooperative Oncology Group (ECOG) performance status ≤2
Candidate for LCT (radiation therapy +/- other local therapies such as surgery, ablation, or embolization) to all sites of progressive disease.
Metastatic effusion (e.g. pleural effusion or ascites). Note that participants with an effusion that is too small to sample will be eligible for the trial.
Leptomeningeal disease.
Peritoneal carcinomatosis.
Cognitively impaired subjects (e.g. inability to sign informed consent.)