A Study of BL-B01D1 Monotherapy, BL-B01D1 in Combination With Lenvatinib, BL-B01D1 in Combination With PD-1 Monoclonal Antibody, and BL-B01D1 in Combination With PD-1 Monoclonal Antibody and Bevacizumab in Patients With Advanced Hepatocellular Carcinoma

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorSichuan Baili Pharmaceutical Co., Ltd.

About this trial

This study is a clinical study to explore the efficacy and safety of BL-B01D1 monotherapy, BL-B01D1 in combination with lenvatinib, BL-B01D1 in combination with PD-1 monoclonal antibody, and BL-B01D1 in combination with PD-1 monoclonal antibody and bevacizumab in patients with advanced hepatocellular carcinoma.

Eligibility criteria

Qualifiers

Sign the informed consent form voluntarily and follow the protocol requirements;

Gender is not limited;

Age ≥18 years old and ≤75 years old;

Expected survival time ≥3 months;

Disqualifiers

Patients with active central nervous system metastases;

Who had participated in any other clinical trial within 4 weeks before the trial dose;

Received anti-tumor therapy such as chemotherapy, radiotherapy and biological therapy within 4 weeks before the first use of study drug;

Had undergone major surgery (investigator-defined) within 4 weeks before the first dose;

Trial design

Treatments tested in this trial

  • BL-B01D1
  • Lenvatinib
  • Finotonlimab
  • Bevacizumab

Treatment groups

74 Participants
are divided into 1 treatment group

Sponsors and collaborators

Sichuan Baili Pharmaceutical Co., Ltd.

Lead sponsor

Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Collaborator