The objective of this study is to evaluate the efficacy, safety, and tolerability of bupivacaine liposomes for paravertebral nerve block in the treatment of thoracoscopic postoperative pain, and to evaluate the relevant human pharmacokinetics.
Subjects who are willing to strictly follow the clinical trial protocol to complete this study and voluntarily sign informed consent;
Elective surgical subjects undergoing lobectomy by single-aperture thoracoscope under general anesthesia;
age ≥18 years old , Male or female;
18 kg/m2≤BMI≤30 kg/m2;
Abnormal laboratory results during screening.
Abnormal renal function: serum creatinine (Cr) ≥1.5×ULN, or dialysis subjects.
Abnormal coagulation function: PT> upper normal value +3s and/or APTT > upper normal value +10s.
Platelet (PLT) <80×109/L.