A Study of Macupatide (LY3532226) and Eloralintide (LY3841136), Alone or in Combination, in Adults With Obesity or Overweight and With Type 2 Diabetes

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-75
SponsorEli Lilly and Company

About this trial

The purpose of this study is to investigate weight reduction with macupatide and eloralintide, alone or in combination, in adult participants with obesity or overweight and with type 2 diabetes. Participation in the study will last about 48 weeks.

Eligibility criteria

Qualifiers

Have type 2 diabetes

Have an HbA1c ≥7.5% to ≤10.5% at screening

Have been treated with any of the following, alone or in combination, for at least 3 months prior to screening

Diet and exercise

Disqualifiers

Have any form of diabetes other than type 2 diabetes

Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening

acute myocardial infarction

cerebrovascular accident (stroke)

Trial design

Treatments tested in this trial

  • Macupatide
  • Eloralintide
  • Macupatide Placebo
  • Eloralintide Placebo

Treatment groups

200 Participants
are divided into 4 treatment groups

Sponsors and collaborators