A Study of QL1706 (an Anti-PD-1/CTLA-4 Combined Antibody) Combined With Albumin-bound Paclitaxel and Bevacizumab in the Treatment of Platinum-resistant Recurrent Ovarian Cancer

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18-70
SponsorWest China Second University Hospital

About this trial

* Major objectives To evaluate the efficacy of QL1706 combined with albumin-binding paclitaxel and bevacizumab in the treatment of platinum-resistant recurrent ovarian cancer. * Secondary Purpose To evaluate the safety of QL1706 in combination with albumin-binding paclitaxel and bevacizumab in the treatment of platinum-resistant recurrent ovarian cancer.

Exploratory analysis of the association between the efficacy of the combination regimen and biomarkers.

Eligibility criteria

Qualifiers

Voluntary signing of a written ICF.

Age ≥18 years, ≤75 years, female.

The Eastern Cooperative Oncology Group (ECOG) physical fitness score was 0 or 1.

Expected survival ≥3 months.

Disqualifiers

Ovarian cancer of non-epithelial origin, fallopian tube cancer, primary peritoneal cancer (such as germ cell tumors) , and low-malignant potential ovarian tumors (such as borderline tumors) .

Previous (within 5 years) or concurrent with other malignancies, the local tumors that have been cured (such as basal cell skin cancer, squamous cell skin cancer, superficial bladder cancer, cervical carcinoma in situ, breast carcinoma in situ, etc.) and breast cancer that has not recurred for more than 3 years after radical operation are excluded.

Local recurrence is suitable for patients undergoing surgery.

Previous radiation therapy of the abdomen and pelvis.

Trial design

Treatments tested in this trial

  • QL1706

Treatment groups

39 Participants
are divided into 1 treatment group

Locations

This trial has no locations