A Study of RC48-ADC Combination With Zimberelimab Injection Therapies at Least First-line Platinum-containing Standard Therapy Failed With Recurrent or Metastatic Cervical Cancer

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18+
SponsorRemeGen Co., Ltd.

About this trial

This study will evaluate the efficacy,safety of RC48-ADC in Combination with Zimberelimab Injection for the Treatment ,at least first-line platinum-containing standard therapy failed in HER2-expressing subject with Recurrent or Metastatic Cervical Cancer

Eligibility criteria

Qualifiers

a)Patients with histologically confirmed HER2-expressing recurrent or metastatic cervical cancer who have failed at least 1 line of standard platinum-containing therapy ; b) Not suitable for surgery or radiotherapy;

Voluntarily agreed to participate in the study and signed an informed consent form.

Female, age ≥ 18 years

Expected survival ≥ 12 weeks

Disqualifiers

Have central nervous system metastases and/or carcinomatous meningitis.

Received anti-tumour therapy or participated in another clinical study treatment within 4 weeks prior to the start of study treatment.

Toxicity due to previous antineoplastic therapy has not recovered to NCI-CTCAE (version 5.0) grade 0-1.

Major surgery with incomplete recovery within 4 weeks prior to start of study dosing.

Trial design

Treatments tested in this trial

  • Disitamab Vedotin
  • Zimberelimab

Treatment groups

116 Participants
are divided into 1 treatment group

Sponsors and collaborators