A Study of SHR-A2102 in Combination With Other Anti-tumor Therapies for Resectable Non-small Cell Lung Cancer

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18-70
SponsorShanghai Hengrui Pharmaceutical Co., Ltd.

About this trial

The study is a Phase II study to explore the efficacy and safety of SHR-A2102 in combination with other anti-tumor therapies as perioperative treatment in patients with resectable non-small cell lung cancer.

Eligibility criteria

Qualifiers

Voluntarily participate in this clinical study, understand the research procedures and be able to sign the informed consent form in writing;

Participants must be aged between 18 and 70 years old (inclusive) when signing the informed consent form, and both men and women are eligible;

Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1;

Adequate organ function;

Disqualifiers

With active, known or suspected autoimmune disease of autoimmune disease;

Malignancies other than NSCLC within 5 years prior to randomization;

Has or suspected has a history of pneumonitis / interstitial lung disease or any serve lung diseases which will influence the examination of lung function;

Significant history of cardiovascular and cerebrovascular disease; Significant haemorrhagic disease;

Trial design

Treatments tested in this trial

  • SHR-A2102
  • Adebrelimab
  • Paclitaxel
  • Carboplatin
  • Alomnertinib Mesilate
  • Furmonertini Mesilate
  • Osimertinib Mesylate

Treatment groups

300 Participants
are divided into 2 treatment groups