It is planned to carry out a multicenter umbrella study to find the optimal organ combination and the best radioimmunotherapy combination pattern, so as to improve the survival of NSCLC patients with multiple metastases. At the same time, by using multimodal omics data, machine learning will be employed to construct a prediction model for the abscopal effect, and explore the immunoregulation of organ-specific radiotherapy and biomarkers of the abscopal effect. The main objective is to find the optimal organ combination and the best radioimmunotherapy combination pattern.
Non-small cell lung cancer diagnosed initially through pathological histology.
There are 3-6 metastatic lesions.
No brain metastasis or the lesions are stable.
Negative for driver genes (including EGFR, ALK, ROS, BRAF, MET, RET genes. Note: The above English terms are all gene names).
Those with severe dysfunction of vital organs (heart, liver, kidney).
Those accompanied by other malignant tumors.
Those with uncontrolled heart diseases or having experienced a myocardial infarction within the past six months.
Those with a history of mental illness.
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Treatment groupsSee each treatment group below.