Adebrelimab Plus Chemotherapy as Neoadjuvant Therapy in Resectable NSCLC Harboring Driver Gene Mutations

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorLiaoning Cancer Hospital & Institute

About this trial

This is a prospective, single-arm study to investigate the efficacy and safety of Adebrelimab in combination with paclitaxel for injection (albumin bound) and platinum chemotherapy as neoadjuvant therapy in resectable non-small cell lung cancer harboring driver gene mutations

Eligibility criteria

Qualifiers

Male or female aged ≥18 years.

Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1.

Resectable non-small cell lung cancer harboring driver gene mutations.

At least one measurable disease based on Response Evaluation Criteria in Solid Tumors 1.1.

Disqualifiers

Previously treated with any anti-tumor therapy;

Subject with known autoimmune disease

Subject with known history of testing positive for human immunodeficiency virus (HIV) or known to have acquired immunodeficiency syndrome (AIDS), subject has known active hepatitis B or C.

Presence of third space effusion that cannot be controlled by drainage or other means (e.g., excessive pleural fluid and ascites).

Trial design

Treatments tested in this trial

  • Adebrelimab
  • paclitaxel for injection (albumin bound)
  • Cisplatin or Carboplatin

Treatment groups

36 Participants
are divided into 1 treatment group

Locations

This trial has no locations