Adjuvant Adebrelimab Plus Apatinib for Participants With HCC at High-risk of Recurrence After Curative Resection

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorQilu Hospital of Shandong University

About this trial

This is a single-center, single-arm, open-label clinical study to evaluate the efficacy and safety of Adebrelimab plus Apatinib as adjuvant therapy in hepatocellular carcinoma (HCC) participants who are at high risk of recurrence after curative resection.

Eligibility criteria

Qualifiers

Voluntarily participate in this study and sign an informed consent form.

Participants diagnosed with HCC through pathological histology/cytology or clinically diagnosed with HCC according to the Diagnosis and Treatment Guidelines for Primary Liver Cancer (2024 Edition).

Within 4-12 weeks prior to enrollment, radical resection surgery was performed.

Complete recovery from surgical resection within 4 weeks prior to enrollment.

Disqualifiers

Known hepatobiliary carcinoma, sarcoma like hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma,and fibrous layer cell carcinoma; Within 5 years or simultaneously suffering from other active malignant tumors other than hepatocellular carcinoma (excluding cured skin basal cell carcinoma and cervical carcinoma in situ).

There are uncontrollable extrahepatic metastases, such as lung and brain metastases (EHS).

Previously received local treatment, including therapeutic TACE, transarterial embolization (TAE), hepatic artery infusion chemotherapy (HAIC), transarterial radiation embolization (TARE), etc.

Participants who are preparing to undergo or have previously received organ or allogeneic bone marrow transplantation.

Trial design

Treatments tested in this trial

  • Adebrelimab + Apatinib

Treatment groups

30 Participants
are divided into 1 treatment group