AG Combined With Immunotherapy and SBRT in Patients With Potentially Resectable Pancreatic Cancer

Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

About this trial

The objective of this study is to evaluate the efficacy and safety of concurrent chemoradiotherapy combined with immunotherapy in patients with potentially resectable pancreatic cancer.

Eligibility criteria

Qualifiers

Age >= 18 years;

Eastern Cooperative Oncology Group (ECOG) score of 0-1;

Pancreatic cancer confirmed by histology or cytology;

Potentially resectable pancreatic cancer documented by contrast enhanced CT (or MRI) scan;

Disqualifiers

Have received systematic anti-tumor treatment.

Previous history of other tumors, except for cervical cancer in situ, treated squamous cell carcinoma or bladder epithelial tumor (TA and TIS) or other malignant tumors that have received radical treatment (at least 5 years before enrollment).

Active bacterial or fungal infection (> = level 2 of National Cancer Institute Common Toxicity Criteria (NCI-CTC), Version 3.0).

Human immunodeficiency virus (HIV), hepatitis C virus (HCV), hepatitis B virus (HBV) infection, uncontrollable coronary artery disease or asthma, uncontrollable cerebrovascular disease or other diseases considered by researchers to be out of the group.

Trial design

Treatments tested in this trial

  • Toripalimab
  • Gemcitabine
  • Nab paclitaxel
  • SBRT

Treatment groups

108 Participants
are divided into 1 treatment group

Sponsors and collaborators

The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Lead sponsor

The First Affiliated Hospital with Nanjing Medical University

Collaborator

Fudan University

Collaborator

Shanghai Changzheng Hospital

Collaborator

The First Affiliated Hospital of Soochow University

Collaborator

Xuzhou Central Hospital

Collaborator