Alpha-1 Blockade for Alcohol Use Disorder (AUD)
ConditionAlcohol Use Disorder (AUD)
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorBrown University
About this trial
The goal of this research is to replicate findings previously conducted in a pilot trial and to understand, mechanistically, the role of stress in the development of AUD pharmacotherapies that target noradrenergic blockade.
Eligibility criteria
Qualifiers
Male or female, 18 years of age
Meet the DSM-5 criteria for AUD
Desire to reduce or quit alcohol drinking
Breath alcohol (BrAC) = 0.00 at each visit
Disqualifiers
Women who are breastfeeding or /positive urine test for pregnancy
CrCl<60mL/min
Suicide attempt in the last three months
Current diagnosis of other substance disorder other than nicotine as assessed by self-report and urine toxicology screen at baseline
Trial design
Treatments tested in this trial
- Doxazosin
- Placebo
Treatment groups
184 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov