An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer

Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18+
SponsorAkeso

About this trial

An Exploratory, Multi-cohort Phase II Study of Combination Therapy With AK104 and AK112 for Recurrent Ovarian Cancer

Eligibility criteria

Qualifiers

Signs the written informed consent form.

Female participants who are at least 18 years of age on the day of signing informed consent with.

ECOG of 0 or 1.

Life expectancy ≥ 3 months.

Disqualifiers

Other pathological types such as mucinous cancer, low-grade serous carcinoma, carcinosarcoma, sex cord stromal cell tumor, etc.

Presence of central nervous system (CNS) metastases or carcinomatous meningitis.

Subjects with uncontrollable pleural, pericardial, or peritoneal effusion requiring repeated drainage.

Patients with other active malignancies within 3 years prior to randomization.

Trial design

Treatments tested in this trial

  • AK104
  • AK112
  • Chemotherapy

Treatment groups

172 Participants
are divided into 4 treatment groups

Sponsors and collaborators