Antarctic Krill Oil for Knee Osteoarthritis Pain
Trial statusNot yet recruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age45-75
SponsorQilu Hospital of Shandong University
About this trial
The goal of this clinical trial is to evaluate the effectiveness and safety of Antarctic Krill Oil (AKO) as a dietary supplement in managing pain associated with knee osteoarthritis (OA). The main questions it aims to answer are:
①Does AKO reduce daily pain intensity in participants with moderate knee OA?
②What adverse effects do participants experience when taking AKO?
Researchers will conduct a randomized, double-blind study comparing AKO to a placebo (identical appearance without active components) to assess:
* Changes in joint pain severity; ②Functional improvement in daily activities; ③Biochemical safety parameters,etc.
Eligibility criteria
Qualifiers
Aged 45-75 years；
Clinically diagnosed with knee osteoarthritis per the Chinese Guidelines for the Diagnosis and Treatment of Osteoarthritis (2018 edition) issued by the Chinese Medical Association, with Kellgren-Lawrence grade 1-3；
Knee pain Visual Analog Scale (VAS) score between 4.0 and 8.0；
Ability to comprehend and complete VAS and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) assessments；
Disqualifiers
Ipsilateral hip osteoarthritis;
Diagnosis of rheumatoid arthritis (RA), ankylosing spondylitis, sarcoidosis, amyloidosis, or any other inflammatory arthritis (e.g., gout, pseudogout);
Chronic pain syndromes, fibromyalgia, or comorbidities that may confound knee pain assessment;
Pain intensity in the lower extremities or back equal to or greater than knee pain;
Trial design
Treatments tested in this trial
- Krill oil
- Olive Oil
Treatment groups
116 Participants
are divided into 2 treatment groupsLocations
Sponsors and collaborators
Source ClinicalTrials.gov