Aspirin for Postpartum Patients With Preeclampsia
ConditionPreeclampsia Postpartum
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexFemale
Age18+
SponsorMemorialCare Health System
About this trial
The purpose of this research study is to evaluate the effect of low-dose aspirin on recovery from severe preeclampsia (a high blood pressure disorder of pregnancy) among women who have given birth. We hypothesize that taking aspirin for the first week after giving birth will enhance recovery from preeclampsia by decreasing the levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to be a main contributor to the development of preeclampsia, and speeding up return to a normal blood pressure.
Eligibility criteria
Qualifiers
Preeclampsia with severe features diagnosed during delivery admission, as defined by ACOG criteria.
Pre- and postnatal care provided by the Long Beach Memorial Ob/Gyn resident or Maternal-Fetal Medicine clinic.
Disqualifiers
Patient age <18 years old
Non-English or Non-Spanish speaking
Chronic hypertension diagnosed before 20 weeks' gestation
Known allergy, prior adverse reaction, or any medical condition in which aspirin is contraindicated (nasal polyps, gastric or duodenal ulcers, history of gastrointestinal bleeding, severe hepatic dysfunction)
Trial design
Treatments tested in this trial
- Aspirin 81Mg Ec Tab
Treatment groups
86 Participants
are divided into 2 treatment groupsSponsors and collaborators
MemorialCare Health System
Lead sponsor
University of California, Irvine
Collaborator
Source ClinicalTrials.gov