About this trial
The goal of this clinical trial is to learn if low-dose atropine eye drops work to reduce excessive watery eyes (epiphora) in adults. It will also learn about the safety of the eye drops.
The main questions it aims to answer are:
Do the eye drops reduce how often participants have watery eyes? What medical problems do participants have when taking the eye drops?
Researchers will compare two strengths of the eye drops (0.005% and 0.01%) to see whether one works better than the other and whether the lower strength works as well as the higher one.
Participants will:
* Use the assigned eye drops in the affected eye(s) for one week * Visit the clinic twice for checkups and eye tests * Receive a follow-up phone call about two weeks after starting, to check on any symptoms
Eligibility criteria
Qualifiers
Are 18 years or older
Have vision of 20/200 or better in at least one eye
Have watery eyes (epiphora) bad enough to need wiping or dabbing at least twice a day
Have watering caused by a functional/idiopathic, gustatory ("crocodile tears"), environmentally triggered (reflex), or obstructive cause - in one or both eyes
Disqualifiers
None
Trial design
Treatments tested in this trial
- Atropine ophthalmic solution
Treatment groups
Sponsors and collaborators
Rehan Ahmed
Lead sponsor
Greater Houston Eye Consultants
Sponsor institution