Atropine Eye Drops for Watery Eyes (Excessive Tearing)

ConditionEpiphora
Trial statusRecruiting
Trial phasePhase 2
Trial typeInterventional
Biological sexAll
Age18+
SponsorRehan Ahmed

About this trial

The goal of this clinical trial is to learn if low-dose atropine eye drops work to reduce excessive watery eyes (epiphora) in adults. It will also learn about the safety of the eye drops.

The main questions it aims to answer are:

Do the eye drops reduce how often participants have watery eyes? What medical problems do participants have when taking the eye drops?

Researchers will compare two strengths of the eye drops (0.005% and 0.01%) to see whether one works better than the other and whether the lower strength works as well as the higher one.

Participants will:

* Use the assigned eye drops in the affected eye(s) for one week * Visit the clinic twice for checkups and eye tests * Receive a follow-up phone call about two weeks after starting, to check on any symptoms

Eligibility criteria

Qualifiers

Are 18 years or older

Have vision of 20/200 or better in at least one eye

Have watery eyes (epiphora) bad enough to need wiping or dabbing at least twice a day

Have watering caused by a functional/idiopathic, gustatory ("crocodile tears"), environmentally triggered (reflex), or obstructive cause - in one or both eyes

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Atropine ophthalmic solution

Treatment groups

18 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Rehan Ahmed

Lead sponsor

Greater Houston Eye Consultants

Sponsor institution