This trial will investigate the combination of two low-cost, non-toxic strategies to assess whether they can reduce the risk of acute major wound complications in soft tissue sarcoma of the lower extremity. Intranasal mupirocin ointment twice daily and chlorhexidine body cleanser once daily for 5 days prior to radiation therapy and repeated for 5 days every 2 weeks during radiation therapy may significantly reduce the risk of acute radiation dermatitis. That, along with use of indocyanine green (ICG) angiography at the time of wound closure.
Eastern Cooperative Oncology Group (ECOG) performance status (PS) 0-2
Newly diagnosed soft tissue sarcoma arising from the lower extremity (defined as the tumor center arising at the level of the iliac crest or below)
Eligible for wide local excision
Eligible for external beam radiation therapy
Allergy to mupirocin and/or chlorhexidine
Active dermatologic condition in RT field
Tumor size > 32cm
Prior RT overlapping with fields
Adam Olson
Lead sponsor
University of Pittsburgh
Sponsor institution
Pittsburgh Cure Sarcoma
Collaborator